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KMID : 0383819610080010065
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Tuberculosis and Respiratory Diseases
1961 Volume.8 No. 1 p.65 ~ p.67
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Urine PAS Test in Pulmonary Tuberculosis Patients Treated on Ambulatory Base
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이효근(李孝根)/Hyo-Keun Lee
홍진근(洪鎭根)/이기용(李起鏞)/박성옥(朴性玉)/민범식(閔範植)/최용옥(崔容玉)/함성숙(咸聖淑)/Jin-Keun Hong/Ki-Yong Lee/Sung-Ok Park/Bum-Shik Min/Yong-Ok Choi/Sung-Sook Ham
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Abstract
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Para-aminosalicylic acid(PAS) is frequently used in conjunction with other
antituberculous agents in the combined therapy of tuberculous agents in the combined
therapy of tuberculosis. Many patients do not tolerate PAS in adequate doses because of
side effects or the inconvenience of ingesting many tablets of relatively large size
throughout the day. Furthermore, it is the general experience among physicians working
with tuberculous patients that many who do not take the drug do not inform their
physicians of this fact or vigorously deny their lack of adherence to a prescribed
program.
Five hundred and seventeen ambulatory pulmonary tuberculosis patients prescribed
PAS as one of their antimicrobial drugs were subjected to a urine PAS test and were
questioned by a physician at one of four clinics.
The percentage of patients with negative urine PAS tests varied considerablly from
clonic to clinic, but averaged 13.7 per cent.
The percentage of negative tests was higher among female patients than among male.
Negative rates increased in the age group from 20 to 49 and was considerably lower
under 19 and above 50 years of age.
Negative rates were higher in patients with less extensive disease and with negative
bacteriologic findings. Negative rates were higher in patients with less education and in
those not those not charged for their drugs.
Negative rates increased also with the length of time that PAS was prescribed. After
19 months of therapy, however, this trend was reversed.
Persuation and adequate explanation of the necessity of regular chemotherapy will
reduce the incidence of negative tests for urine PAS.
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